Suspension Presentation

Each 5 ml Contains:
Ofloxacin IP     50 mg
Ornidazole IP   125 mg

The combination of Ofloxacin and Ornidazole shows synergistic action to treat certain bacterial infections.

Indications

• Used to treat urinary tract infection
• Respiratory tract infection
• Used to treat ameobiasis
• In giardiasis
• In trichomonas’s vaginitis infections

About Composition

Ofloxacin:

Ofloxacin is second generation fluoroquinolone antibiotic it works by inhibiting the enzyme DNA gyrase and prevents the super-coiling and replication of the DNA of the bacteria

Ornidazole:

Ornidazole is belongs to synthetic nitro-imidazole derivative class and kills anaerobic bacteria and protozoa so that is why it is used to treat anaerobic bacterial and protozoal infections

Mechanism of Action

Ofloxacin:

Ofloxacin works by inhibiting the enzyme DNA gyrase and topoisomerase IV of the bacteria which is similar to the human topoisomerase and thus prevents the super-coiling of DNA during replication or transcription.

Ornidazole:

It works by inhibiting the nucleic acid synthesis by releasing the nitro radical which binds with bacterial protein and thus disrupting the DNA of microbes.

Side Effects

• Somnolence (strong desire to sleep).
• Headache
• Nausea
• Vertigo
• Mixed peripheral neuropathy
• Nephrotoxicity

Contraindications

• Contraindicated in patients with known hypersensitivity.
• Contraindicated in pregnant women

Storage

• Store in cool place away from light.
• Shake well before use.